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5'-(N-ethylcarboxamido) adenosine improves angiogenesis in transplanted human ovarian tissue |
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| Authors: | Hormozi Maryam Talebi Saeed Zarnani Amir Hassan Jeddi-Tehrani Mahmood Gohari Ladan Hosseini Soltanghoraei Haleh Jafarabadi Mina Akhondi Mohammad Mehdi |
| Institution: | a Biochemistry Department, Tehran University of Medical Sciences, Tehran, Iran b Reproductive Biotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran c Biochemistry Department, Lorestan University of Medical Sciences, Korramabad, Iran d Nanobiotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran e Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran f Monoclonal Antibody Research Center, Avicenna Research Institute (ACECR), Tehran, Iran g Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran |
| Abstract: | To investigate the effect of 5'-(N-ethylcarboxamido) adenosine (NECA), an adenosine agonist, on triggering angiogenesis in transplanted human ovarian tissue, the expression of angiopoietin-1 (Ang1), Ang2, vascular endothelial growth factor 121 (VEGF-121) and VEGF-189 at both gene and protein levels as well as the density of vasculature were studied in tissue fragments grafted to NECA-treated and control groups of nude mice. The results showed that NECA treatment triggered down-regulation of Ang1, induced VEGF-189 expression, and stimulated neovascularization, highlighting the beneficial effect of NECA on the process of angiogenesis. |
| Keywords: | Angiopoietin fertility preservation human ovarian cortex NECA nude mice transplantation VEGF |
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