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Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study |
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| Authors: | Ladson Gwinnett Dodson William C Sweet Stephanie D Archibong Anthony E Kunselman Allen R Demers Laurence M Lee Peter A Williams Nancy I Coney Ponjola Legro Richard S |
| Affiliation: | a Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee b Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, Pennsylvania c Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania d Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania e Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania f Department of Kinesiology, Penn State College of Health and Human Development, University Park, Hershey, Pennsylvania g Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia |
| Abstract: | Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life. |
| Keywords: | Ovarian function insulin action nutrition exercise androgen |
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