血清视黄醇结合蛋白4与非酒精性脂肪肝病的相关性研究

目的分析血清视黄醇结合蛋白4（RBP4）在非酒精性脂肪肝病（NAFLD）患者中的水平,探讨血清RBP4与NAFLD的相关性。方法分别测定85例NAFLD患者和94例健康对照组的体重指数（BMI）、血压及生化指标,采用Pearson’s相关分析,研究RBP4与BMI、SP、DP、ALT、GGT、FBG、TG等检测因素的相关性。结果NAFLD组血清RBP4水平显著高于对照组（64.6±15.1）mg/LVs（53.7±13.4）mg/L],P〈0.001）;采用Pearson’s单相关分析显示,血清RBP4水平与ALT、HOMA、GGT显著正相关（P〈0.01）,与GGT相关关系密切（r=0.486,P〈0.001）;多因素Logistic回归分析显示,血清RBP4是与NAFLD相关联的独立影响因子（P=0.004;OR（95%CI）：1.055（1.020-1.103））。结论血清RBP4水平与NAFLD及肝细胞凋亡和损伤标志物显著相关。

Study on the relationship between retinol-binding protein 4 and non-alcoholic fattyliver disease

Objective To analyse the levels of Retinol-binding protein 4 （RBP4） in patients with non-alcoholic fattyliver disease （NAFLD）,We investigated the relationship between NAFLD and serum RBP4.Methods BMI、blood pressure、biochemical indicator were determined in 85 NAFLD patients and 94 contol people.The correlation between retinol binding protein and BMI、SP、DP、ALT、GGT、FBG、TG were analyzed with pearson＇s correlation analysis.Results Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group （64.6 ± 15.1）mg/lv（s53.7 ± 13.4）mg/L],P0.001）.Serum RBP4 levels were positively correlated with serum alanine aminotransferase （ALT）,HOMA,especially with γ-glutamyltranspeptidase（GGT） levels（r=0.486,P0.001）.Multiple logistic regression analysisrevealed that the RBP4 level was an independent factor associatedwith NAFLD（P=0.004;OR（95%CI）：1.055（1.020-1.103））.Conclusion Serum RBP4 levels are significantly associated withNAFLD and liver enzymes.