| erbB-2/HER-2在肺癌组织中的异常表达及意义 |
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| 引用本文： | 田彬,陈永立,查昭宇,王柳环,刘隆平.erbB-2/HER-2在肺癌组织中的异常表达及意义[J].贵州医药,2003,27(12):1073-1074. |
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| 作者姓名： | 田彬 陈永立 查昭宇 王柳环 刘隆平 |
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| 作者单位： | 贵阳市肺科医院,550006 |
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| 摘 要： | 目的 研究erbB-2／HER-2基因在肺癌组织中的异常表达的意义。方法 应用免疫组织化学的方法检测50例肺癌和20例正常肺组织HER-2(人体第二表皮生长因子受体，Human epidermal-growth—factor receptor2，HER2)蛋白的表达。结果 HER-2／neu在正常肺组织中无过表达，肺癌组织中存在HER-2／neu的过表达，过表达率为66％，肺癌HER-2／neu的过表达更多见于中晚期肺癌，特别是肺腺癌，且与患者术后无瘤三年生存率呈负相关。结论 HER-2／neu可作为评价肺癌(特别是肺腺癌)患者预后的可靠指标。
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| 关 键 词： | erbB-2 HER-2 肺癌 异常表达 癌组织 |
Study on erbB-2 HER-2abnormal expression in lung cancer |
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| Tian Bin,Chen Yongli,Zha Zhaoyu,et al..Study on erbB-2 HER-2abnormal expression in lung cancer[J].Guizhou Medical Journal,2003,27(12):1073-1074. |
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| Authors: | Tian Bin Chen Yongli Zha Zhaoyu |
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| Institution: | Tian Bin,Chen Yongli,Zha Zhaoyu,et al.The Guiyang City Lung Disease Hospital,Guiyang 550006 |
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| Abstract: | Objective To investigate the erbB-2 abnormal expression in lung cancer.Methods 20 sampleS of paraffin-embedded normal lung tissues and 50 samples of parattm-embedded lung cancer from the patients with lung cancer were examined for erbB-2 expression by immunohistochemistry.Results HER-2 was underexpressed in normal lung tissues and overexpressed in lung cancer.The HER-2 overexpression in lung cancer was associated with clinical stage (66%) and reversly correlated with postoperative survival especially in adenocarcinoma lung cancer. Conclusion The HER-2 tends to be apptaised the development of lung cancer and it is a mark for the credibility prognosis of lung cancer. |
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| Keywords: | Lung cancer erbB-2 gene HER-2 protein |
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