原发性高血压患者血压变异性与尿微量白蛋白/尿肌酐比值研究

目的：探讨原发性高血压患者血压变异性（BPV）与尿微量白蛋白/尿肌酐的关系。方法：103例符合入选标准的原发性高血压患者作为高血压组，并选96例健康体检者作为对照组，予24h监测动态血压、血压变异性及尿微量白蛋白，比较两组血压变异性与尿微量白蛋白/尿肌酐的关系。结果：各组患者在年龄、性别、吸烟史、总胆固醇、甘油三酯、空腹血糖以及体重指数等指标方面比较无差异性(P>0.05)，高血压组患者昼间SBPV、夜间SBPV和24h SBPV均显著高于对照组(P<0.01)；高血压组尿微量白蛋白、尿微量白蛋白/尿肌酐比值显著高于对照组(P<0.05)。结论：血压变异程度与尿微量白蛋白/尿肌酐具有相关性，可预测高血压早期的肾功能损害。

The relevant research between blood pressure variability and microa/buminuria in primary hypertension patients

Objective:To investigate the relationships between blood pressure variability and micro albumin in primary hypertension patients. Methods:There were 103 hypertensive patients were recruited in this study and 96 healthy volunteers as control group. The 24h ambulatory blood pressures, BPV and ratio of micro albumin and creati-nine were recorded by detecting instrument. The relationship between blood pressure variability and the ratio of micro albumin and creatinine in each group were compared. Results:There were no significantly difference of Age, Sex, GLU, TG, TC in two group patients (P>0.05), and the hypertension variability in primary hypertension patients, com-pared to those in control group had significantly difference ( P<0.05), there are significantly differences of the level of micro albumin,the ratio of micro albumin and creatinine between two groups ( P<0.05). Conclusion: Hypertension variability is associated with the ratio of micro albumin and creatinine, which can predict renal damages in hypertensive early.