| 缝隙连接胞间通讯对大脑中动脉缺血后海马迟发性神经元死亡的影响 |
| |
| 引用本文： | 焦莉,徐沙贝,唐荣华,骆翔,王伟.缝隙连接胞间通讯对大脑中动脉缺血后海马迟发性神经元死亡的影响[J].中国现代医学杂志,2008,18(18):2625-2627,2631. |
| |
| 作者姓名： | 焦莉 徐沙贝 唐荣华 骆翔 王伟 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院神经内科,湖北,武汉,430030 |
| |
| 基金项目： | 国家自然科学基金资助项目(30600187); 国家杰出青年基金项目(30725019); 湖北省自然科学基金资助项目(2007ABA174) |
| |
| 摘 要： | 目的 观察探讨星型胶质细胞缝隙连接胞间通讯变化对大鼠大脑中动脉缺血再灌流后海马区迟发性神经元死亡(DND)的影响.方法 建立大鼠短暂性大脑中动脉缺血再灌流模型.利用尼氏染色、TUNEL方法 观察再灌流后星型胶质细胞缝隙连接蛋白抑制剂CBX对海马DND的影响.结果 大脑中动脉缺血再灌流后3 d、7 d海马神经元明显脱失,部分CA1、CA2区神经元凋亡;应用CBX后TUNEL阳性神经元数目明显减少,幸存神经元数目增加.结论 星型胶质细胞缝隙连接蛋白抑制剂CBX可有效抑制大鼠大脑中动脉缺血后海马神经元DND.
|
| 关 键 词： | 缝隙连接胞间通讯 星型胶质细胞 迟发性神经元死亡 |
Hippocampus after focal cerebral ischemia with electrophysiological recording spreading depression |
| |
| JIAO Li
,
XU Sha-bei
,
TANG Rong-hua
,
LUO Xiang
,
WANG Wei.Hippocampus after focal cerebral ischemia with electrophysiological recording spreading depression[J].China Journal of Modern Medicine,2008,18(18):2625-2627,2631. |
| |
| Authors: | JIAO Li XU Sha-bei TANG Rong-hua LUO Xiang WANG Wei |
| |
| Institution: | JIAO Li,XU Sha-bei,TANG Rong-hua,LUO Xiang,WANG Wei (Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan,Hubei 430030,P.R.China) |
| |
| Abstract: | Objective] To explore the effect of astrocyte gap junction intracellular communication on the delayed neuronal death in rat hippocampus after global ischemia. Methods] A rat model of transient global ischemia was used to observe the effect of CBX (astrocyte gap junction intracellular communication) on delayed neuronal death in the hippocampus by Nissel dyeing, TUNEL techniques. Results] Hippocampal neurons were significantly lost 3 and 7 days after transient global ischemia , part of the neurons in CA1 a... |
| |
| Keywords: | gap junction intracellular communication astrocyte DND |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
