氟比洛芬乙基纤维素水分散体包衣小丸的制备及体外释药特性

目的：制备氟比洛芬包衣小丸，评价其体外释药特性。方法：离心造粒法制备空白丸芯及载药小丸；以乙基纤维素水分散体为包衣材料，羟阿基甲基纤维素为致孔剂，流化床制备氟比洛芬包衣小丸；释放度实验考察小丸的体外释药特性。结果：包衣小丸缓释胶囊的释放曲线与进口缓释胶囊ForbensR相似，羟丙基甲基纤维素的用量和介质pH值对释药影响显著，而热处理时间和胶囊壳对释药无显著性影响。结论：氟比洛芬包衣小丸具有较理想的体外缓释效果。

Preparation and release characteristics in vitro of flurbiprofen pellets coated with ethylcellulose aqueous dispersion

Objective: To prepare flurbiprofen coated pellets and evaluate its release characteristics in vitro.Methods:Sugar core beads and drug-containing pellets were prepared by centrifugal granulation.The pellets was coated with ethylcellulose aqueous dispersion as coating material and HPMC as porous agent by fluid-bed.The release characteristics in vitro of the pellets were investigated by the dissolution trials.Results: The release profile of the coated pellets was similar to that of imported sustained-release capsule Forben SR.The release rate of flurbiprofen was influenced markedly by the content of HPMC and pH value of the release medium,not influenced by heat treatment time and capsule shell.Conclusion: The pellets exhibit relatively ideal sustained-release characteristics in vitro.