HEMOPOIESIS-STIMULATING ACTION OF ADAMANTYLAMIDE DIPEPTIDE: KINETICS OF INCREASE OF GM-CFC IN FEMUR AND CO-STIMULATING ACTIVITY OF SERUM, ROLE OF BONE MARROW STROMAL CELLS |
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Authors: | A Vacek M Hofer L Weiterov Z Hoferov I Pipalov K Ma ek |
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Institution: |
a Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
b Institute of Pharmacology, Academy of Sciences of the Czech Republic, Praha, Czech Republic |
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Abstract: | Chief part of hemopoietic stromal cells in mediating hemopoiesis-stimulating effects of adamantylamide dipeptide (AdDP), a synthetic immunomodulatory compound, has been determined in a series of combined in vivo/in vitro studies. Indirect stimulatory effect of AdDP on proliferation of hemopoietic progenitor cells for granulocytes and macrophages (GM-CFC) was proved to be mediated by the cells of hemopoietic microenvironment growing as adherent stromal cell populations in vitro. These results supplement previously reported findings of a positive role which is played by AdDP at modulating the interplay among stimulatory cytokines and their cellular sources, and are in consent with the idea to introduce AdDP as a constituent of the hemopoiesis- and immunity-stimulating supportive medical care. |
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