胸腺瘤合并单纯红细胞再生障碍性贫血(附5例报道)

目的 探讨胸腺瘤合并单纯红细胞再生障碍性贫血（PRCA）的临床特征及外科治疗方法.方法 回顾分析1979年至2004年间5例胸腺瘤合并PRCA病人的临床资料.结果 男2例,女3例;年龄43～68岁,平均54.6岁,均获根治性切除.胸腺瘤合并PRCA者占同期胸腺瘤病人的2.7%（5/185例）.术后早期PRCA情况明显改善,术后长期生存4例,1例复发死亡.结论 胸腺瘤合并PRCA是一种少见疾病,外科治疗是本病的首选治疗手段.对单纯红细胞再生障碍性贫血不能缓解者给予激素和免疫抑制剂治疗,可望取得较好疗效.

The clinical study on thymoma associated with pure red cell aplasia: report of five cases

Objective To present the clinic characteristics of thymoma associated with pure red cell aplasia. Methods Between 1979 and 2004, 5 patients with thymoma associated with pure red cell aplasia were surgically treated. Results The age of the patients ranged from 43 to 68 years, mean age 54.6 years. The incidence of thymoma associated with pure red cell aplasia was 2.7% (5/185) in the contemporary series. All five patients underwent radical operation. The early results of thymomectomy were excellent, 4 cases are long-term survivals, and recurrence of PRCA was found in one patient 2 months after operation and died 31 months later. Conclusion Thymoma associated with PRCA is a rare autoimmune disease. Surgery for thymoma is still the top priority in the selection of treatment. Incretion and immunosuppressor may be considered for postoperative persistent PRCA cases.