纳络酮2种剂量治疗急性脑梗死的效果比较

目的观察2种剂量纳络酮治疗急性脑梗死的效果。方法80例急性脑梗死患者采用随机单盲法分成2组,小剂量组40例为常规治疗+纳络酮1.2mg/d;大剂量组40例为常规治疗+纳络酮4.0mg/d。比较2组患者治疗前、后神经功能缺损评分及不良反应情况。结果大、小剂量纳络酮均能有效改善急性脑梗死患者神经功能缺损评分(P<0.05);治疗后3d,大剂量组神经功能改善程度较小剂量组更为显著(P<0.05),治疗后10d及30d,2组神经功能缺损评分无显著性差异(P>0.05)。小剂量组不良反应发生率和严重性及产生的药物费用均明显低于大剂量组。结论与大剂量纳络酮治疗脑梗死比较,小剂量纳络酮不但治疗有效,且不良反应发生率及治疗费用均更低,值得临床推广。

Naloxone for Acute Cerebral Infarction: Comparison of 2 Doses

OBJECTIVE: To observe the efficacy of high and low dose of naloxone on acute cerebral infarction. METHODS: 80 patients with acute cerebral infarction were randomly divided into 2 groups by single blind method: 40 in the low dose group were assigned to receive routine treatment plus naloxone 1.2mg/d,another 40 in high dose group to receive routine treatment plus naloxone 4.0mg/d. Neurologic impairment scales and adverse reactions were compared between 2 groups before and after treatment. RESULTS: Patients with acute cerebral infarction in either high or low dose naloxone group showed neurologic improvement(P<0.05). On the 3rd day after treatment,patients in high dose group had a higher degree of neurologic improvement than in the low dose group(P<0.05),but no statistically significant differences were noted between 2 groups on the 10th and 30th day after treatment (P>0.05).Incidences and severity of ADRs and drug costs in low dose group were all significantly lower than in high dose group. CONCLUSIONS: The low dose naloxone group is more effective,lower in both ADR incidences and drug costs for acute cerebral infraction as compared with high dose group,therefore,the low dose of naloxone is preferable.