大蒜、燕麦及其复合物对高脂大鼠血管内皮细胞活性物质的影响

目的　探讨大蒜、燕麦及其复合物对高脂大鼠血浆一氧化氮(NO)、PGI2 和TXA2 的影响,为预防高血脂和动脉粥样硬化提供理论依据。方法　选择健康大鼠60只,随机分为5组,每组12只,分别用普通饲料、高脂饲料、大蒜、燕麦及大蒜燕麦复合物饲喂8周,测定NO、PGI2 及TXA2 含量。结果　用大蒜、燕麦及大蒜燕麦复合物对高脂大鼠饲喂8周后,LGF组、HGF组和GOCF组的NO和PGI2 显著升高、TXA显著下降(P <0 .0 1) ;而饲喂普通饲料无明显变化,饲喂高脂饲料组的大鼠NO显著下降、TXA2 显著升高(P <0 .0 1) ;GOCD组NO和PGI2 的升高、TXA2 的下降尤为显著(P <0 .0 1)。结论　大蒜和燕麦均具有明显的调节脂质代谢和影响血管内皮细胞活性物质生成的作用,能够显著升高NO和PGI2 以及降低TXA2 ,而用低剂量的大蒜素和燕麦组合的复合饲料进行营养干预,其效果明显优于单用大蒜和燕麦,这对促进机体脂质代谢,预防高血脂和动脉粥样硬化具有重要意义。

Effects of garlic and oat and their combination on activity substances in vascular endothelial cells in hyperlipidemic rats

Objective To observe the effects of garlic and oat and their combination on plasma nitrogen monoxide (NO), prostaglandin I 2 (PGI 2), and thromboxane A 2 (TXA 2) in hyperlipidemic rats. Methods A total of 60 healthy adult Wistar rats were divided into five groups randomly (n = 12 in each group). These rats were fed in different cages and with basic forage, high fat forage, low garlicin forage (LGF), high garlicin forage (HGF), and garlicin and oat compound forage (GOCF) for 8 weeks. The contents of plasma NO, PGI 2, and TXA 2 in rats were determined. Results After these hyperlipidemia rats were fed with low garlicin forage, high garlicin forage, and compound forage for 8 weeks, the contents of serum NO and PGI 2 increased significantly, and the contents of plasma TXA 2 decreased significantly in LGF, HGF, and GOCF group. However, the indices in the normal forage group remained unchanged. At the same time, the contents of serum NO and decreased significantly, but the contents of plasma TXA 2 increased significantly in HFF. Compare with those in LGF and HGF groups, the contents of serum NO and PGI 2 increased significantly, but the contents of plasma TXA 2 decreased significantly in GOCF. Conclusion Garlic and oat, which can increase the contents of serum NO and PGI 2 and decrease the contents of plasma TXA 2, have antiatherogenic and protective effects on the functions of vascular endothelial cells, and may facilitate lipid metabolism and prevent hyperlipidemia and artherosclerosis.