肝硬化非曲张静脉破裂出血与血清促胃液素、胃液酸度及门静脉内径关系探讨

目的　探讨肝硬化非曲张静脉破裂出血与血清促胃液素、胃液酸度及门静脉内径的关系。②方法采用放射免疫法测定血清促胃液素含量 ;胃酸直接滴定法测定胃液酸度 ;B型超声法测量门静脉内径。③结果肝硬化非曲张静脉破裂出血者血清促胃液素、胃液酸度及门静脉内径与对照组比较 ,差异有显著性 (t =2 .87～4.95 ,P <0 .0 1)。门静脉压力与胃液酸度存在负相关关系 (r=- 0 .712 ,P <0 .0 1)。④结论　血清促胃液素的升高并非是造成肝硬化非曲张静脉破裂的原因 ;门静脉压力的升高是导致非曲张静脉破裂出血的根本原因 ;即使低胃酸状态也会对胃黏膜屏障构成损害 ,故抑制胃酸治疗是必要的。

A STUDY ON RELATIONSHIP OF NONVARICOSE-RUPTURE HEMORRHAGE OF CIRRHOSIS WITH SERUM GASTRIN, ACIDITY OF GASTRIC JUICE AND THE INNER DIAMETER OF PORTAL VEIN

Objective To study the relationship of nonvaricose rupture hemorrhage of cirrhosis with serum gastrin, acidity of gastric juice and the inner diameter of portal vein. Methods The level of serum gastrin was measured by radioimmunoassay, acidity of gastric juice by direct titration and the inner diameter of portal vein by ultrasonography. Results There were significant differences of serum gastrin and acidity of gastric juice as well as the inner diameter of cirrhotic patients with nonvaricose rupture hemorrhage compared with the control group( t=2.87-4.95, P <0.01) . There was a negative correlation of portal pressure and acidity of gastric juice ( r= -0.712, P <0.01). Conclusion The elevation of serum gastrin was not the cause of nonvaricose rupture hemorrage in patients with cirrhosis. The basic reason of hemorrhage was due to the increase of portal vein pressure. Hypoacidity may cause damage to mucous membrane barrier. To inhibit gastric acid is necessary.