146例严重药品不良反应报告分析

目的分析严重药品不良反应（ADR）报告表，探讨预防严重ADR发生的方法。方法对146例严重ADR报告表，分别按患者年龄、性别、报告人职业、引起ADR的药品、给药途径、临床表现等方面进行回顾性统计分析。结果146例严重ADR中，静脉给药方式引起的严重ADR例数最多（89例，60．96％），其次为口服给药（52例，35．62％）；抗菌药物引起的严重ADR最多，其次为心脑血管药物和中药制剂；ADR临床表现以过敏性休克、药物性肝炎、重症皮疹等表现为主；90例严重ADR导致住院或住院时间延长，42例危及生命。结论严重ADR的发生与多种因素有关，应增强合理用药意识，以减少和避免严重ADR的发生，保证药物治疗安全、有效。

Analysis on 146 serious adverse drug reaction reports

Objective Analysis of serious adverse drug reaction （ADR） report, discuss the method to prevent occur- rence of serious ADR. Methods According to patient age, gender, occupation, reported by ADR pharmaceuticals, route of administration, clinical manifestation were retrospectively analyzed. Results 146 cases of severe ADR,intravenous adminis- tration induced severe ADR cases were the most （89 cases,60.96%）, followed by oral administration （52 cases,35. 62% ） ;severe ADR antibacterial drug induced the most ,followed by cardiovascular drugs and traditional Chinese medicine; clinical manifestations of ADR in anaphylactic shock, drug - induced hepatitis, severe rash ;90 cases of severe ADR causing or prolonging hospitalization,42 cases of life - threatening. Conclusion Genesis is related to multiple factors of severe ADR,should strengthen the consciousness of rational drug use,to reduce and avoid the occurrence of serious ADR,ensure safe, effective drug treatment.