| 半边旗有效成分5 F对腹膜炎小鼠血清NO和细胞因子的影响 |
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| 引用本文： | 叶华,龚先玲,李立,吴科锋,吕应年,符伟玉,郑学宝. 半边旗有效成分5 F对腹膜炎小鼠血清NO和细胞因子的影响[J]. 山东医药工业, 2014, 0(12): 683-685 |
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| 作者姓名： | 叶华 龚先玲 李立 吴科锋 吕应年 符伟玉 郑学宝 |
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| 作者单位： | 广东天然药物研究与开发重点实验室、广东医学院,广东湛江524023 |
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| 基金项目： | 国家自然科学基金（No.30772701）;广东省科技计划项目（No.2009C3104003）;湛江市科技攻关项目（No.2012C3104019,2013A01008）;广东医学院重点项目（No.Z2013001）、面上项目（No.M2013003）和博士启动项目（No.B2013019） |
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| 摘 要： | 目的：研究半边旗有效成分贝壳杉烷型二萜类化合物5F对腹膜炎小鼠血清一氧化氮（NO）和细胞因子IL-6、IL-10、TNF-α、MCP-1的影响。方法预先给予50和100 mg·kg-15F溶液3 d后，腹腔注射50 mg·kg-1酵母多糖建立腹膜炎模型，Griess法测一氧化氮含量，流式细胞术检测IL-6、IL-10、TNF-α和MCP-1的水平。结果与模型组比较，5F可以降低腹膜炎小鼠血清一氧化氮水平（ P﹤0.05），减少IL-6、IL-10、TNF-α和MCP-1含量（P﹤0.05或P﹤0.01）。结论5F可以有效减少酵母多糖诱导的腹膜炎小鼠血清一氧化氮、TNF-α、IL-6、IL-10和MCP-1含量。
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| 关 键 词： | 半边旗 腹膜炎 一氧化氮 细胞因子 |
Effect of 5F,an extract from Pteris semipinnata L. serum NO and cytoKine levels in zymosan A-induced peritonitis mice |
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| YE Hua,GONG Xian-ling,LI Li,WU Ke-feng,LV Ying-nian,FU Wei-yu,ZHENG Xue-bao. Effect of 5F,an extract from Pteris semipinnata L. serum NO and cytoKine levels in zymosan A-induced peritonitis mice[J]. , 2014, 0(12): 683-685 |
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| Authors: | YE Hua GONG Xian-ling LI Li WU Ke-feng LV Ying-nian FU Wei-yu ZHENG Xue-bao |
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| Affiliation: | ( Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Zhanjiang 524023, China ) |
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| Abstract: | Objective To investigate the effect of 5F,an extract from Pteris semipinnata L. serum NO and cytokine levels in zymosan A-induced peritonitis mice. Methods After pretreatment with 50 and 100 mg·kg-1 5F solution for 3 d,mice were intraperitoneal injection of 50 mg·kg-1 zymosan to induce peritonitis. The release of nitric oxide was meas-ured by a Griess reagent system. The serum levels of IL-6,IL-10,TNF-αand MCP-1 were determined by flow cytome-try. Results Compared with model group,5F pretreatment could decrease the overproduction of NO,IL-6,IL-10,TNF-αand MCP-1（P﹤0. 05 or P﹤0. 01）. Conclusion 5F could significantly reduce the serum level of NO,TNF- α,IL-6,IL-10 and MCP-1 in zymosan A-induced peritonitis mice. |
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| Keywords: | Pteris semipinnata L. Peritonitis NO Cytokine |
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