孕激素治疗子宫内膜癌的形态学观察与治疗机理探讨

目的：通过孕激素对子宫内膜腺癌治疗后的形态观察，而探讨其治疗机理。方法：对我院经孕激素治疗并手术切除的４２例子宫内膜腺癌标本及３４例未用孕激素治疗的子宫内膜腺癌诊刮标本，进行光镜、电镜的腺癌细胞形态学观察。结果：孕激素治疗后的腺癌细胞分化趋向成熟，其分泌活跃，同时，还在癌组织中观察到凋亡的腺癌细胞。未经孕激素治疗的子宫内膜腺癌细胞，其组织排列紊乱，极性消失，有些腺体呈背靠背现象。结论：孕激素对肿瘤细胞有直接作用，使癌细胞生长受抑，促使其分化转向成熟，术前与术后应用孕激素治疗，可减少腹腔种植及转移，减少术后复发机会。

The Mechanisms of Progesterone Treatment on Endometrial Carcinoma

Objective: To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma. Methods: We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy. Results: The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells. Conclusions: Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.