妊高征患者外周血清及单核细胞内镁,钙含量测定

目的：探讨镁、钙代谢在妊高征病理生理变化中的作用。方法：采用原子吸收分光光度测定法（火焰原子化法），测定了２６例妊高征患者（妊高征组）产前外周血清及单核细胞内镁、钙含量，以２７例同期住院的正常晚期妊娠妇女作对照（对照组）。结果：妊高征组与对照组比较：（１）妊高征组外周血清镁、钙含量显著降低（Ｐ＜０．０１及Ｐ＜０．０５）；（２）中、重度妊高征患者外周血单核细胞内镁含量显著降低（Ｐ＜０．００１及Ｐ＜０．０１）；（３）中、重度妊高征患者外周血中单核细胞内的钙含量显著降低（Ｐ＜０．０１及Ｐ＜０．０５）。结论：镁、钙含量降低可能在妊高征病理生理变化中起重要作用。

Magnesium and Calcium Concentration of Peripheral Serum and Mononuclear Cells in Patients with Pregnancy Induced Hypertension

Objective: To evaluate the magnesium and calcium concentration of peripheral serum and mononuclear in patients with pregnancy induced hypertension (PIH). Methods: Twenty six patients with PIH and 27 healthy women in their late pregnancy were studied. The serum and mononuclear cells magnesium and calcium contents were measured with atomic absorption spectrophotometry (fire atomization). Results: When compared with the healthy women in their late pregnancy, (1) the peripheral serum magnesium and calcium contents in patients with PIH decreased significantly ( P <0.01 and P <0.05), (2)the magnesium contents of the peripheral mononuclear cells in patients with moderate and severe degrees of PIH decreased significantly ( P <0.001 and P<0.01) , (3) the calcium contents of the peripheral mononuclear cells in patients with moderate and severe degrees of PIH decreased significantly ( P <0.01 and P <0.05). Conclusion: The decrease of magnesium and calcium concentration may be one of the important factors responsible for the pathophysiologic changes of PIH.