多发性骨折后全身炎症反应综合征的监控

目的　分析多发性骨折后全身炎症反应综合征 (SIRS)的监测因素。方法　将 87例多发性骨折患者分为SIRS组、非SIRS组和死亡组 ,比较各组血清肿瘤坏死因子 (TNF -α)、粒细胞集落刺激因子 (G -CSF)、补体C3 、免疫球蛋白 (IgG)等的变化。同时观察失血量分级与SIRS的关系。结果　SIRS组G -CSF和IgG水平明显低于非SIRS组 ,TNF -α水平明显高于非SIRS组 (P <0 .0 5 ) ;死亡组G -CSF、补体C3 及IgG水平较SIRS组进一步降低 ,TNF -α水平进一步升高 (P <0 .0 5 )。随失血量增大 ,SIRS发生率、病死率升高 (P <0 .0 5 )。结论　G -CSF ,IgG ,TNF -α水平及失血量可作为SIRS的监控指标。

Monitor of systemic inflammatory response syndrome after multiple fracture

Objective It is to analyze the monitoring factor of systemic inflammatory response syndrome (SIRS) after multiple fracture.Methods 87 patients with multiple fractures were divided into SIRS group, non-SIRS group and death group. The changing of TNF-α, G-CSF, alexin C 3 and IgG in each group and the relationship between SIRS and loss of blood were observed.Results In SIRS group, the levels of G-CSF and IgG were obviously lower while the level of TNF-αwas obviously higher than those in non-SIRS group (P<0.05). In death group, the levels of G-CSF, alexin C 3 and IgG were ulteriorly lower and the level of TNF-α was ulteriorly higher than those in SIRS group (P<0.05). The morbidity and death rate of SIRS rose when the loss of blood augmented.Conclusion The levels of G-CSF, IgG and TNF-αand the loss of blood can be chosen as the monitoring index of SIRS.