CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES : VI. COOPERATIVE RESPONSES BETWEEN LYMPHOCYTES DERIVED FROM MOUSE DONOR STRAINS DIFFERING AT GENES IN THE S AND D REGIONS OF THEH-2 COMPLEX |
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Authors: | David H. Katz Martin E. Dorf Baruj Benacerraf |
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Affiliation: | From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 |
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Abstract: | In our initial studies on the question of histocompatibility requirements in T-B-cell interactions, we found that no cooperation occurred with mixtures of T and B cells from BALB/c (H-2d) and A/J (H-2a) donors, respectively (1). These particular strains are identical for genes in the S and D regions of the H-2 complex but possess major differences at the K-end. Many differences are known to exist in the I region as well. Thus, these early data indicated that gene identities only at the D-end are insufficient to permit optimal cooperative interactions to occur under these conditions. |
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