Physiopathology and therapy of severe cerebral hypoxia

The pathophysiological mechanisms of severe cerebral hypoxia (in men) are discussed: disturbance of autoregulation, vasoparalysis, luxury perfusion, cytotoxic and vasogenic brain swelling, rise of intracranial pressure (ICP), stop of cerebral circulation. Possible trials of therapy are presented: restitution of cardiovascular circulation, controlled hyperventilation, control of ICP, dexamethason bolus, early high-dose barbiturates.