Akt和mTOR在皮肤基底细胞癌中的表达

目的 检测Akt和雷帕霉素靶蛋白（mammalian target of rapamycin， mTOR）在皮肤基底细胞癌( basal cell carcinoma, BCC)中的表达情况，探讨Akt/mTOR信号通路在BCC发病机制中的作用及其临床意义。方法 免疫组织化学方法检测37例BCC以及16例正常皮肤标本中的Akt和mTOR蛋白的表达情况。结果 BCC中Akt蛋白的阳性表达率为62.2%，mTOR蛋白的阳性表达率为83.8%，与正常皮肤组织中Akt蛋白的阳性表达率12.5%和mTOR蛋白的阳性表达率37.5%相比，显著增高(均为P<0.05)。Akt和mTOR的表达水平在BCC中存在正相关，有统计学意义(均为P<0.05)。结论 Akt和mTOR在BCC中的过度表达,提示Akt/mTOR通路可能是BCC发生发展的机制之一。

Expression of Akt and mTOR in tissue of cutaneous basal cell carcinoma

ABSTRACT】Objective To investigate the role of Akt/ mTOR signal pathway in the pathogenesis of basal cell carcinoma by observing the expressions of Akt and mTOR in basal cell carcinoma，and their clinical significances. Methods Immunohistochemical method was applied to detect the expressions of　Akt and mTOR in skin specimens including 37 cases of basal cell carcinoma and 16 cases of normal skin. Results The rate of positive expression of Akt in basal cell carcinoma and normal skin tissue were 62.2%,12.5% respectively. The rate of positive expression of mTOR in basal cell carcinoma and normal skin tissue were 83.8%, 37.5% respectively. There were significant differences between normal skin tissues and basal cell carcinoma in the expression of Akt and mTOR (P<0.05). There were significantly positive correlation between the expression of Akt and mTOR in basal cell carcinoma. Conclusion Akt/mTOR signal pathway may play an important role in the pathogenesis of basal cell carcinoma.