| 抗VCAM-1单克隆抗体联合光动力疗法治疗大鼠C6脑胶质瘤的研究 |
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| 引用本文： | 詹奇,胡韶山. 抗VCAM-1单克隆抗体联合光动力疗法治疗大鼠C6脑胶质瘤的研究[J]. 中国激光医学杂志, 2011, 20(4): 205-208,269,270 |
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| 作者姓名： | 詹奇 胡韶山 |
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| 作者单位： | 哈尔滨医科大学附属第二医院神经外科,哈尔滨市,150086 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的探讨抗VCAM-1单克隆抗体联合光动力疗法（PDT）对大鼠脑C6胶质瘤生长的抑制作用。方法建立C6脑胶质瘤模型,成瘤动物分4组,即PDT＋VCAM-1抗体组、PDT组、VCAM-1抗体组和对照组。观察各组VCAM-1表达、凋亡指数、大鼠生存时间、肿瘤体积、计算抑瘤率。结果 PDT组和VCAM-1抗体组均能抑制肿瘤生长,PDT＋VCAM-1抗体组的抑制作用更显著。PDT组VCAM-1表达增高明显。抗体组VCAM-1表达受到明显抑制。结论 PDT治疗后给予抗VCAM-1单克隆抗体既抑制VCAM-1表达增加,又抑制新血管生成,从而更有效地抑制胶质瘤生长,延长生存时间。
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| 关 键 词： | 光动力疗法 胶质瘤 单克隆抗体 |
Inhibiting Effect of Anti-VCAM-1 Monoclonal Antibody with Photodynamic Ther-apy on in vivo Growth of C6 Glioma Xenografts |
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| ZHAN Qi,HU Shao-shan. Inhibiting Effect of Anti-VCAM-1 Monoclonal Antibody with Photodynamic Ther-apy on in vivo Growth of C6 Glioma Xenografts[J]. Chinese Journal of Laser Medicine & Surgery, 2011, 20(4): 205-208,269,270 |
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| Authors: | ZHAN Qi HU Shao-shan |
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| Affiliation: | ZHAN Qi,HU Shao-shan* Department of Neurosurgery,the Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China |
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| Abstract: | Objective To investigate the effect of anti-VCAM-1 monoclonal antibody with photodynamic therapy(PDT) on the in vivo growth of C6 glioma. Methods Seven days after inoculation with C6 cells,rats with MRI-confirmed glioma were randomly assigned to 4 groups(n=15):the PDT + antibody group;PDT group;vascular cell adhesion molecule-1(VCAM-1) antibody group and control group.Eight days after inoculation,hematoporphyrin monomethyl ether(HMME) was administered as a photosensitizer and PDT was performed at 630 nm(ill... |
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| Keywords: | Photodynamic therapy Glioma Monoclonal antibody |
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