乙型肝炎患者血浆D一二聚体水平与肝功能储备状态的关系

探讨乙型肝炎患者血浆D．二聚体（D-D）含量与肝功能储备状态的关系。方法、根据肝功能储备状态，将77例乙型肝炎患者分成肝功能代偿组44例，肝功能失代偿组33例，两组测定血浆D．二聚体、凝血酶原时间（PT）和肝功能指标。结果肝功能失代偿组患者血浆D．二聚体含量（299．0±498．5）μg/L显著高于肝功能代偿组（27．9±34．0）彬L（t=3．1，P〈0．01）；D．二聚体与血清白蛋白（ALB）和凝血酶原活动度（PA）呈显著负相关（r=-0．6、-0．6，均P〈0．01）；而与TBIL和P，r呈显著正相关（r=0．4、0．6，均P〈0．01）。结论乙型肝炎患者血浆D一二聚体水平与肝功能储备状态相关，检测D．二聚体有助于肝功能储备的评估和预后的判断。

Analysis of the relationship between plasma D-dimer and hepatic functional reserve status in patients with hepatitis B

Objective To investigate the relationship between the level of plasma D-dimer(D-D) and hepatic functional reserve status in patients with hepatitis B (HB).Methods 77 cases with HB were divided into two groups, hepatic function compensated group and hepatic function decompensated group.Plasma D-D, hepatic functional indexes and PT of all patients were detected.Results The level of D-D in the hepatic function decompensated group was higher than that in the hepatic function compensated group(299.0 ± 498.5) μg/L vs (27.9 ± 34.0) μg/L(t =3.1, P ＜ 0.01).D-D negatively correlated with ALB and PA(r =-0.6,-0.6, all P ＜ 0.01), and positively correlated with TBIL and PT(r = 0.4,0.6, all P ＜ 0.01).Conclusion The level of plasma D-D related with hepatic functional reserve status,and detecting the level of D-D could be helpful to estimate hepatic functional reserve and prognosis of patients with HB.