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Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: a retrospective cohort study |
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| Authors: | Armand Mekontso Dessap Islem Ouanes Nerlep Rana Beatrice Borghi Christophe Bazin Sandrine Katsahian Anne Hulin Christian Brun-Buisson |
| Institution: | 1. AP-HP, Groupe Henri-Mondor Albert-Chenevier, Service de Reanimation Medicale, 51 avenue du Mal de Lattre de Tassigny Creteil, Chevilly-Larue, F-94010, France 2. INSERM, Unite U955, 51 avenue du Mal de Lattre de Tassigny, Creteil, F-94010, France 3. Faculté de Medecine, Universite Paris 12, 8 avenue du Général Sarrail, Creteil, F-94010, France 4. Intensive Care Unit, Fattouma Bourguiba University Hospital, avenue Farhat HACHED, 5000, Monastir, Tunisia 5. AP-HP, Groupe Henri-Mondor Albert-Chenevier, Laboratoire de Pharmacologie et Toxicologie, 51 avenue du Mal de Lattre de Tassigny, Creteil, F-94010, France 6. AP-HP, Groupe Henri-Mondor Albert-Chenevier, Unité de Reherche Clinique, 51 avenue du Mal de Lattre de Tassigny, Creteil, F-94010, France |
| Abstract: | IntroductionRecent publications suggest potential benefits from statins as a preventive or adjuvant therapy in sepsis. Whether ongoing statin therapy should be continued or discontinued in patients admitted in the intensive care unit (ICU) for sepsis is open to question. |
| Keywords: | statin discontinuation blood concentration sepsis |
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