Relevance of biofilms in pediatric tonsillar disease |
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Authors: | R R Diaz S Picciafuoco M G Paraje N A Villegas J A Miranda I Albesa D Cremonezzi R Commisso and P Paglini-Oliva |
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Institution: | (1) Department of Otolaryngology, Reina Fabiola Clinic, Catholic University of C?rdoba, C?rdoba, Argentina;(2) Department of Pharmacy, School of Chemical Sciences, National University of C?rdoba, C?rdoba, Argentina;(3) Member of the Research Career of the National Research Council of Argentina (CONICET), Buenos Aires, Argentina;(4) Department of Pathology, School of Medicine, National University of C?rdoba, C?rdoba, Argentina;(5) Department of Biophysics, School of Medicine, National University of C?rdoba, Rapela 3258, Res. V. S?rsfield, 5016 C?rdoba, Argentina; |
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Abstract: | In this investigation, we study the relation between chronic inflammation of the tonsils, clinical features, and the presence
of biofilms in the crypts in patients presenting with obstructive hypertrophy and recurrent upper airway pathology. Thirty-six
patients who needed to undergo a tonsillectomy for obstructive reasons (aged 1 to 6 years), among which none of them had taken
any antibiotics 30 days prior to surgery, were included. Samples were examined with hematoxylin-eosin and Gram staining, fluorescent
microscopy, and confocal laser microscopy. The predominance of symptoms were those related to obstructive pathology rather
than infection (p < 0.01). All patients had tonsillar hypertrophy (grade III or IV), but an association with adenoids hypertrophy was detected
in 66.66% of cases (p < 0.05). 77.28% of tonsils presented biofilms in their crypts, but hypertrophy and tonsillar follicle number were not related
to the presence or absence of biofilms. Here, we demonstrated that symptoms like harsh raucous sound, tonsillar and adenoids
hypertrophy, apnea, and cervical adenopathies are clearly related to the presence of biofilm in tonsils. Our results allow
us to propose that biofilms are involved in the pathogenesis of tonsils and adenoids hypertrophy. The prevention of biofilms
formation should be focused in the early stages, attempting to restrain bacterial attachment to the respiratory mucosa. |
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