治疗手足口病中药的模糊聚类分析

目的:对治疗手足口病的中药进行归类,为临床的复方组方应用提供启发和思路.方法:收集2000年1月至2010年12月期刊杂志公开发表文献,治疗例数在20人以上的中药复方126首,选出使用频次＞10次的40味中药,基于药性(含归经)和功效的多个变量,用SPSS 19统计软件对其进行模糊数学中的聚类分析方法.结果:通过对样本按优化原则进行4,6,8类分类,发现药物聚为4类时较好,这4类药是清热药、解表药、化湿药和利水渗湿药.结论:运用聚类分析的方法可以较好地将不同类别而却有相似功效的药物归类,同时发现治疗手足口病的用药类别与传统的中医理论有着密切的联系,这对深入研究临床治疗手足口病的用药有着较为重要的意义.

Fuzzy Clustering Analysis for Hand Foot and Mouth Disease in Treatment with Traditional Chinese Medicines

Objective:To classify traditional Chinese medicines in treatment of the hand foot and mouth disease(HFMD) to provide a new way for the further study on the formula rules and clinical application of these traditional Chinese medicines. Method:The data were collected from January, 2000 to December, 2010.From more than 126 Chinese herbal compounds which were used to 20 cases effectively and havd 10 or more frequency,40 compounds were chosen. Based on the property of a medicine including the channel tropism and the effect of multiple variables,all the paper were published in the journals. The SPSS 19 software package was used, and the distribution of traditional Chinese medicines were dealt with cluster and correlative analysis, which were based on fuzzy mathematics. Result:Through clustering method,different categories were separated, using the principle of optimization,The data were divided into 4, 6 and 8 categories. The cluster analysis showed that 4 categories was better. The four kinds of medicine were belongs to heat clearing, diaphoretic, resolving dampness drug and eliminating dampness through diuresis medicine. Conclusion:The cluster analysis method can be used to classify different classes and havs similar efficacy of traditional Chinese medicines.There is a relation between the treatment of Hand Foot and Mouth Disease and the theory of traditional Chinese medicine,which is significant for the further study on clinical application of these traditional Chinese medicines.