Acute myelomonocytic leukemia with bone marrow eosinophilia and inv(16)(p13q22),t(1;16)(q32;q22) |
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Authors: | M Y Yip P Sharma L White |
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Institution: | Cytogenetics and Cell Biology Unit, Prince of Wales Hospital, Sydney, N.S.W., Australia. |
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Abstract: | A two-year-old girl presenting with de novo acute myelomonocytic leukemia with eosinophilia (French-American-British FAB] classification, M4Eo) and inv(16)(p13q22), t(1;16)(q32;q22) involving the same chromosome 16 is described. This is the second report of a variant translocation of an inverted chromosome 16 with chromosome 1 at 1q32. However, the segment 1q32----1qter has been exchanged for 16q22----qter and not 16p13----pter, as reported in the previous case. The additional break at 1q32 and the juxtaposition of 1q32----qter onto chromosome 16 could be relevant to the pathogenesis of the disease. |
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