测定甲状腺激素在判断重症病例预后中的价值

目的:通过测定重症疾病患者甲状腺激素(TH),判断其在病情严重程度及疾病预后中的价值.方法:把重症疾病分为三组,分别采用放射免疫分析(RIA)测定血清甲状腺激素进行对照,并作统计学处理.结果:与正常人组比较重症疾病组血清T3、FT3显著降低,rT3浓度升高,T4、FT4、TSH无明显变化.结论:非甲状腺疾病重症病例血清T3、rT3、FT3含量变化与疾病严重程度相关,激素含量在治疗中的变化预示疾病转归情况.

Clinical Value of Determination of Serum Thyroid Hormones Levels for Outcome Prediction in Patients with Critical Illness

Objective To explore the value of determination of serum thyroid hormones levels for outcome prediction in critical illness. Methods Serum thyroid-related hormones (T3, FT3, rT3, T4, FT4, TSH) levels were measured with RIA dynamically for three times during 15 days of treatment in 182 patients with various kinds of critical illness (cardiac, respiratory, hepatic, renal failures). Results The serum T3, FT3 levels were significantly lowered and rT3 levels significantly increased in these critical patients (vs normal values of this laboratory). The T4, FT4, TSH levels were not much changes. Conclusion Changes of serum T3, FT3 and rT3 levels in patients with critical illness were closely related to the severity of the disease process and were useful for outcome prediction.