| 阿托伐他汀对老年2型糖尿病患者颈动脉硬化的影响 |
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| 引用本文： | 郭远,孙立新,李卫,李飞颖,张学武. 阿托伐他汀对老年2型糖尿病患者颈动脉硬化的影响[J]. 中华老年心脑血管病杂志, 2008, 10(10): 757-759 |
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| 作者姓名： | 郭远 孙立新 李卫 李飞颖 张学武 |
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| 作者单位： | 北京大学人民医院,北京,100044 |
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| 摘 要： | 目的探讨阿托伐他汀对老年2型糖尿病患者颈动脉硬化的影响。方法选择100例合并颈动脉硬化的老年2型糖尿病患者,随机分为对照组50例(仅控制血糖)和联合组50例(在控制血糖基础上,口服阿托伐他汀20mg/晚),疗程为12个月。测定治疗前后颈动脉硬化相关指标、血脂及高敏C反应蛋白(hs-CRP)。结果两组患者治疗前颈动脉内膜中层厚度(IMT)、斑块检出率、斑块Crouse积分及颈动脉内径无显著差异;与治疗前比较,对照组治疗12个月后颈动脉IMT、斑块检出率及Crouse积分明显增加(P<0.05),颈动脉内径、血脂及hs-CRP水平无明显变化;联合组治疗12个月后颈动脉IMT、斑块检出率、Crouse积分明显降低,颈动脉内径明显增加(P<0.05),治疗6个月、12个月后血清LDL-C、TG、TC、hs-CRP明显降低,HDL-C明显升高(P<0.05)。IMT、Crouse积分均与LDL-C、TG、TC、hs-CRP呈正相关,与HDL-C呈负相关(P<0.05)。结论在控制血糖的同时,联合应用阿托伐他汀,对延缓老年2型糖尿病患者颈动脉硬化进展有一定影响。
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| 关 键 词： | 糖尿病,非胰岛素依赖型 颈动脉疾病 降血脂药 降血糖药 阿托伐他汀 |
Effect of atorvastatin on carotid atherosclerosis in elderly patients with type 2 diabetes mellitus |
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| GUO Yuan,SUN Li-xin,LI Wei,et al. Effect of atorvastatin on carotid atherosclerosis in elderly patients with type 2 diabetes mellitus[J]. Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, 2008, 10(10): 757-759 |
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| Authors: | GUO Yuan SUN Li-xin LI Wei et al |
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| Affiliation: | GUO Yuan,SUN Li-xin,LI Wei,et al (People Hospital,Peking University,Beijing 100044,China) |
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| Abstract: | Objective To investigate the effects of atorvastatin on carotid atherosclerosis in elderly patients with type 2 diabetes mellitus(T2DM).Methods One hundred elderly patients with T2DM and carotid atherosclerosis were randomly divided into two groups.Control group was treated with hypoglycemic drugs alone;while combination group was treated with both atorvastatin(20 mg/d) and hypoglycemic drugs.The carotid atherosclerosis parameter and the serum levels of lipid and high-sensitive C reactive protein(hs-CRP) we... |
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| Keywords: | diabetes mellitus non-insulin-dependent carotid artery diseases antilipemic agents hypoglycemic agents atorvastatin |
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