细胞核仁形成区活性与反复自发流产相关性的探讨

目的：探讨细胞核仁形成区活性与反复自发流产的关系。方法：应用银梁ＮＯＰ技术，对反复自发注产患者夫妇和有正常史夫妇各３０对的中期染色体核二形成区银梁点（Ａｇ－ＮＯＲ）和近端着丝粒梁色体银梁联合（Ａｇ－ＡＡ）数进行对比分析。结果：反复自发流冰夫妇Ａｇ－ＮＯＲ数量和女性Ａｇ－ＡＡ）数进行对比分析。结果：反笔自发流产夫妇Ａｇ－ＮＯＲ数量和妇性Ａｇ－ＡＡ次数分别为６．７２，６．３９和０．３７明显高于对照组的６．０７，５，８６和０．３１，二者间有显著性差异（Ｐ〈０．０１，Ｐ〈０．０５），结论：细胞核仁形成区活性增高是引起反复自发流产的重要因素。

Relationship Between the Activity or Nucleolar Organizer Regions and Recurrent Spontaneous Abortion

Objective To observe the relationship between the activity of nucleolar organizer regions (NOR) and the spontaneous abortion. Methods The Ag-NOR and Ag-AA numbers of the metaphase chromosomes in 30 couple with recurrent spontaneous abortion and 30 normal couple were analysed contrastively by the silver staining technique.Results The Ag-NOR numbers in cells of the couple with spontaneous abortion and the Ag -AA in cells of the women from the couple were 6. 72, 6. 39 and 0. 37, respectively. And those of control group were 6. 07, 5. 86 and 0. 31, The statistically significant differences were revealed between: them (P <0. 01, P <0.05). Conclusion The activity of nucleolar organizer regions increasing is one of the important factors causing spontaneous abortion.