曲安奈德与鱼肝油治疗非糜烂型口腔扁平苔藓的临床观察

目的:探讨局部涂擦曲安奈德或鱼肝油治疗非糜烂型口腔扁平苔藓的疗效.方法:将128例非糜烂型口腔扁平苔藓患者随机分为实验组(66人)和对照组(62人),实验组采用局部涂擦曲安奈德;对照组采用局部涂擦鱼肝油.比较2组患者初诊和治疗1周后的疼痛指数VAS值及3周后的综合判定疗效.结果:实验组1周后疼痛指数明显降低(P＜0.05),且低于对照组,两者差异有统计学意义(P＜0.05);实验组3周后综合疗效数值明显高于对照组(P＜0.05),两者差异有统计学意义(P＜0.05).实验组治疗前后疼痛指数比较,两者差异有统计学意义(P＜0.001);对照组治疗前后疼痛指数比较,两者差异有统计学意义(P＜0.001).治疗3周后综合疗效数值中,实验组的白色损害面积变化与疼痛指数变化具有相关性(P＜0.05),实验组粘膜充血程度改变与疼痛指数变化具有相关性(P＜0.05),对照组的白色损害面积变化与疼痛指数变化具有相关性(P＜0.05),对照组黏膜充血程度改变与疼痛指数变化没有相关性(P＞0.05).结论:曲安奈德较鱼肝油治疗非糜烂型口腔扁平苔藓具有更好的疗效.

Clinical observation of triamcinolone acetonaide acetate inunction locally and cod liver oil a Liq inunction locally in treatment of oral lichen planus of non-erosion type

Objective: To explore the effects of Triamcinolone acetonaide acetate inunction locally and cod liver oil a Liq inunction locally in clinical treatment of patients with oral lichen planus of non-erosion typeJtfethods:A total of 128 selected patients with oral lichen planus of non-erosion type in clinic were randomly divided into experimental group (n=66) and control group (n=62). Patients in experimental group underwent the treatment of Triamcinolone acetonaide acetate inunction locally;while patients in control group underwent the treatment of cod liver oil a liq. inunction locally only. The pain index value at preliminary diagnosis and one week after treatment were evaluated, and the curative effect index value three weeks after treatment were compared between the two groups. Results: The evaluation of pain index reduced obviously (P＜0.05)in experimental group one week after treatment And there was statistical significance between the two groups (P＜0.05 ).The index of comprehensive curative effect in experimental group was better than than in control group, which shewed statistical significance between the two groups (P＜0.05). It shewed statistical significance when compared the evaluation of pain in experimental group on prior-treatment and post-treatment (P＜ 0.001), It also shewed statistical significance when compared the evaluation of pain in control group on prior-treatment and post-treatment (P＜0.001 ).To compare the curative effect index value three weeks after treatment, there were dependability between the change of alba-damage-area and the change of pain index value in experimental group (P＜0.05). There were dependablity between the change of mucous hyperemia degree and the change of pain index value in experimental group (P＜0.05). There were dependablity between the change of alba-damage-area and the change of pain index value in control group (P＜0.05 ). There were no dependablity between the change of mucous hyperemia degree and the change of pain index value in control group (P＞0.05).Conclusion: Triamcinolone acetonaide acetate inunction locally in clinical treatment of patients with oral lichen planus is more effective than cod liver oil a liq inunction locally.