Effect of splenectomy on liver regeneration and polyamine metabolism after partial hepatectomy |
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| Authors: | S Kubo I Matsui-Yuasa S Otani S Morisawa H Kinoshita K Sakai |
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| Institution: | 1. Department of Biochemistry, Osaka City University Medical School, Osaka 545, Japan;1. Second Division, Department of Surgery, Osaka City University Medical School, Osaka 545, Japan;1. Mount Sinai Beth Israel, New York, New York;13. Icahn School of Medicine at Mount Sinai, New York, New York;2. Texas Liver Institute, University of Texas Health Science Center, San Antonio, Texas;3. New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand;4. Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada;5. Ruane Medical and Liver Health Institute, Los Angeles, California;6. ID Care, Hillsborough, New Jersey;7. William Osler Health System, Brampton Civic Hospital, Brampton, Ontario, Canada;8. University of Alberta, Edmonton, Alberta, Canada;9. Emory University, Atlanta, Georgia;10. Atlanta Medical Center, Atlanta, Georgia;11. Gilead Sciences, Inc, Foster City, California;12. James J. Peters Veterans Affairs Medical Center, Bronx, New York;14. Medical Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany;15. Institute of Liver Studies, Kings College Hospital, London, United Kingdom;16. Gastroenterology and Nutritional Medical Services, Bastrop, Louisiana;17. Digestive Care, South Florida Center of Gastroenterology, Wellington, Florida;18. Toronto Western Hospital Liver Centre, Toronto, Ontario, Canada;19. St Vincent''s Hospital Sydney, University of New South Wales Sydney, Sydney, New South Wales, Australia;25. Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia;20. Christchurch Hospital, University of Otago, Christchurch, New Zealand;21. St. Vincent’s Hospital, Melbourne, Victoria, Australia;22. Hôpital Beaujon, Université Paris Diderot, INSERM UMR 1149, Centre de Recherche sur l''Inflammation, Clichy, France;23. Alfred Hospital, Melbourne, Victoria, Australia;24. Royal London Hospital, London, United Kingdom;1. CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain;2. Department of Experimental Immunobiology, Division of Transplantation Immunology and Mucosal Biology, King''s College London, London SE1 9RT, UK;1. Medical University of South Carolina, Charleston, South Carolina;2. ProMedica Toledo Hospital, Toledo, Ohio;3. Emory University Hospital, Atlanta, Georgia;4. Cleveland Clinic Foundation, Cleveland, Ohio;6. Sentara Norfolk General Hospital, Norfolk, Virginia;5. University of Washington Medical Center, Seattle, Washington;7. Drexel University College of Medicine, Philadelphia, Pennsylvania;11. Novant Health Heart and Vascular Institute, Matthews, North Carolina;12. Ohio State University, Columbus, Ohio;8. NAMSA (Biostatistics), Minneapolis, Minnesota;10. Boston Scientific Corporation, St. Paul, Minnesota;9. CorVita Science Foundation, Chicago, Illinois;1. Ecole de Pharmacie Genève-Lausanne (EPGL), University of Lausanne, University of Geneva, Switzerland;2. University of Fribourg, Chair of Pharmacology, Fribourg, Switzerland;3. Institute of Materials, EPFL, Lausanne, Switzerland;4. Dept. of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;5. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;6. The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA;7. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;8. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;9. Interfaculty Bioengineering Institute, EPFL, Lausanne, Switzerland;10. Department of Anesthetics, Pharmacology and Intensive Care, Faculty of Medicine, University of Geneva, Switzerland |
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| Abstract: | The effect of splenectomy on hepatic ornithine decarboxylase (ODC) induction, DNA synthesis, and mitosis of hepatocytes was studied in rat liver after partial hepatectomy. ODC activity markedly increased in the early stages of liver regeneration, and the increase in the activity was significantly enhanced in splenectomized rats. Splenectomy specifically induced ODC since tyrosine aminotransferase and general protein synthesis were not affected. Splenectomy also enhanced increase in hepatic polyamines, DNA synthesis, and mitosis in regenerating liver. The results suggest that splenectomy affects liver regeneration after partial hepatectomy by enhancing induction of ODC activity, which is an important biochemical event in the early stage of liver regeneration. |
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