不同环境对海水浸泡犬复合型颅脑火器伤的影响

目的 探讨陆地与海上不同环境条件对海水浸泡犬复合型颅脑火器伤的影响.方法 成年健康犬30只,制作成复合型颅脑火器伤动物模型(颅脑火器伤+开放性胸部伤+开放性腹部伤+烧伤).动物致伤后随机分为3组,即A组(陆地非海水浸泡)、B组(陆地海水浸泡)和C组(海上海水浸泡),每组10只.采用:Powlab/8sp生理记录仪动态监测体温、呼吸(R)、心率(HR)和平均动脉压(MAP)的变化,监测血气分析和血电解质变化.结果 C组伤情明显重于A组和B组,表现为生命体征紊乱,呼吸明显加快,循环、体温调节功能障碍,低体温,血浆渗透压升高,高钠、高氯血症,代谢性酸中毒,导致动物生存时间缩短,死亡率增加.结论 海上环境对海水浸泡复合型颅脑火器伤犬的生命体征和生化指标均有明显影响.

Effects of different environment on combined injury with craniocerebral firearm wound in dogs immersed by seawater

Objective To investigate effects of different environment of land and sea on combined injury with craniocerebral firearm wound ( CICFW) in dogs immersed by seawater. Methods The model of CICFW including craniocerebral firearm injury,open chest injury, open abdominal injury and burn. The dogs with CICFW were randomly divided into three groups, each of which had 10 dogs; the group Ⅰ(without seawater immersion in land environment) , the group Ⅱ(with seawater immersion in land environment) , and the group Ⅲ( with seawater immersion on sea environment). The changes of vital signs including body temperature, respiration, heart rates and mean arterial pressure were recorded by powlab/8sp electrophysiolograph. The blood gas analysis and electrolytes changes were, monitored. Results The state of an injury was severer in group Ⅲ than that in groupⅠand groupⅡ. Compared with groupⅠand groupⅡ, the respiration and heart rates in group Ⅲ were significantly faster ( P < 0.05). In addition, recirculating system and body heat regulation function were failure in group Ⅲ, as well as low temperature, high plasma osmotic pressure, hypsi-sodium, hyperchloraemia and metabolic acidosis were also vital sign of group El, which of all above them made live time of animals shorten and mortality rate increase. Conclusions The sea environment is one of important influence factors that cause the changes of vital signs and biochemical indicator after CICFW.