妇乐宁缓释药膜的制备与临床应用

目的:研制开发一种新型妇科外用缓释药膜——妇乐宁缓释药膜,观察其对阴道炎的临床疗效.方法:以替硝唑及少量乙酚、B族维生素(维生素B1、维生素B2、维生素B6)、羧甲基纤维素钠、聚乙烯醇等为材料制成膜剂,对滴虫性阴道炎、霉菌性阴道炎、老年性阴道炎、细菌性阴道炎患者共355例应用观察,外用,qd或qod,用药5～7次.结果:对妇乐宁缓释药膜进行了质量控制,妇乐宁缓释药膜对阴道炎总有效率99.15%,其中细菌性阴道炎、霉菌性阴道炎有效率100.0%,未见不良反应.结论:妇乐宁缓释药膜治疗阴道炎疗效好,使用方便,毒副作用小,有良好的推广价值.

Preparation and Clinical Application of Fulening, A Slow- release Membrane Drug

Objective:To prepare and develop a new type of slow release membrane drug Fulening for external use and to survey its clinical therapeutic effectiveness in the treatment of vaginitis. Methods:The drug membrane was prepared with the use of materials including tinidazole, small amount of diethylstilbestrol, and vitamine B 1, vitamine B 2, vitamine B 6, sodium carboxymethyl cellulose, polyvinyl alcohol, etc. It was used externally to treat patients with trichomonal vaginitis, colpomycosis, senile vaginitis and bacterial vaginitis, totaling 355 cases. The drug membrane was used once daily or every other day, for 5 to 7 times. Results:The slow release membrane drug Fulening was subjected to quality control. The overall effective rate in the treatment of vaginitis was 99.2% , while patients with bacterial vaginitis were 100.0% cured. No adverse reactions were noticed. Conclusion:The slow release membrane drug was shown to have a good therapeutic effect in the treatment of vaginitis. It is easy to use, has no toxic and side effects and is therefore worth spreading its application.