Effect of antiphospholipid antibodies in women undergoing in-vitro fertilization: role of heparin and aspirin |
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Authors: | Kutteh WH; Yetman DL; Chantilis SJ; Crain J |
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Institution: | The University of Tennessee, Memphis Health Science Center, USA. |
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Abstract: | To describe the prevalence of antiphospholipid antibodies in women
undergoing in-vitro fertilization (IVF) and to determine if heparin and
aspirin affect implantation rates, 191 women with a history of infertility
undergoing IVF were prospectively tested for antiphospholipid antibodies.
This was a two-centre, non-randomized comparison of women with positive
antiphospholipid antibodies receiving heparin and aspirin versus standard
treatment. An enzyme-linked immunosorbent assay, with referenced standards
and known positive and negative sera on each plate, was utilized to measure
antibodies to cardiolipin, phosphatidylinositol, phosphatidylglycerol,
phosphatidylserine and phosphatidylethanolamine. Statistical analyses of
results included analysis of variance and Fisher's two-tailed exact test.
Antiphospholipid antibodies were detected in 18.8% of patients undergoing
IVF compared with only 5.5% in the 200 normal controls, 26% in 200 women
with recurrent pregnancy loss, and 32% in 200 women with systemic lupus
erythematosus. In conclusion, antiphospholipid antibodies were found more
frequently in women undergoing IVF than in the normal control population.
Although implantation rates appeared higher in the group of women treated
with heparin and aspirin, no statistically significant differences were
detected in implantation, pregnancy and ongoing pregnancy rates between
those who received standard therapy and those treated with heparin and
aspirin.
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