斑秃家族患病调查及其研讨

报道原发性斑秃1210例,发现有家族史者75例(6.2%),其家族中共有患者163例,患病率为14.91%.家族患者之间亲缘关系分属于:Ⅰ级亲属142例(87.12%),Ⅱ级17例,Ⅲ级4例,患者发病在同一个世代者33户,70例;发于两世代40户,87例;三世代2户,6例.有4例单合子双胎,今尚未见其孪生者同发斑秃.对遗传因素与斑秃发病之关系进行了分析研讨.

Genealogical Investigation on Patients with Alopecia Areata

In the genealogical investigation into 1210 patients with alopecia areata(AA),we found 75 cases with a positive family history of AA,the familial incidence was 6.2%.The incidence of AA in the 75 families (1093 cases) was 14.91% (163 cases).In these families,there were 142 patients in first-grade relatives of the family members,17 in second-grade,and 4 in third-grade.We observed 70 cases in 33 families within one generation,87 cases in 40 families within two succesive generations,and 6 cases in 2 families within three successive generations,four pairs of monozygotic twins appeared in this investigation,but just one of each pair was affected.The relationship between pathogenesis of AA and genetic factor has been discussed.