In vitro susceptibility to infection with SIVcpz and HIV-1 is lower in chimpanzee than in human peripheral blood mononuclear cells |
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Authors: | Ondoa Pascale Davis David Kestens Luc Vereecken Chris Garcìa Ribas Sergio Fransen Katrien Heeney Jonathan van der Groen Guido |
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Affiliation: | Institute of Tropical Medicine, Antwerp, Belgium. |
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Abstract: | This study was undertaken to evaluate and compare the susceptibility of chimpanzee versus human peripheral blood mononuclear cells (PBMCs) to infection with SIVcpz and HIV-1 non-syncitium inducing primary isolates. The results demonstrate clearly that chimpanzee PBMCs have a lower capacity to support viral replication as compared to human PBMCs. There was no experimental evidence that this difference was due to a lower availability of target cells for viral infection (PBMCs positive for CD4 and CCR5 molecules) or to a differential susceptibility to apoptosis (PBMCs positive for CD4 and CD95 molecules). A lower capacity of chimpanzee PBMCs to support SIVcpz and HIV-1 replication in vitro is related to a post-entry barrier to virus replication. |
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Keywords: | primate susceptibility to infection viral replication |
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