Myeloperoxidase as a measure of polymorphonuclear leukocyte response in inflammatory status around immediately and delayed loaded dental implants: a randomized controlled clinical trial |
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Authors: | Güncü Güliz N Tözüm Tolga F Güncü M Bari? Yamalik Nermin Tümer Celal Karabulut Erdem Kilinç Kamer |
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Institution: | Clinical instructor, Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey;;associate professor, Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey;;private practice, Ankara, Turkey;;professor, Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey;;associate professor, Department of Oral Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey;;instructor, Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey;;professor, Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey |
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Abstract: | Background: As well as gingival crevicular fluid (GCF), peri‐implant sulcus fluid (PISF) may have a potential diagnostic value for the early identification of metabolic and destructive processes. Purpose: The aim of this study was to analyze the potential impact of inflammation and loading on PISF myeloperoxidase (MPO) levels, in comparison with GCF. Materials and Methods: A total of 220 sites, dental implant (immediately IL] or delayed loaded DL]), and natural tooth, either healthy/noninflamed or gingivitis/inflamed, were classified. Clinical parameters were recorded, and GCF/PISF samples were obtained. GCF/PISF MPO levels were spectrophotometrically determined. Results: Clinical parameters demonstrated increases with the presence of gingival/peri‐implant inflammation. Total MPO levels were higher at inflamed tooth and implant sites compared to noninflamed/healthy sites (p < .05). Although they did not reach a significance level, inflamed IL sites had higher total MPO levels than inflamed DL sites (p = .401). Gingival index and total MPO levels exhibited significant correlations (p < .05). Conclusion: Using implants and natural teeth in the same study design, the findings of the present study support the close relationship between MPO production and inflammation, and may speculate a potential for loading of dental implants, contributing to the MPO content of PISF. |
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Keywords: | dental implants inflammation loading myeloperoxidase natural tooth |
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