原发性肝癌HBV感染模式与AFP水平相关性研究

目的:探讨原发性肝癌(PHC)患者乙肝病毒(HBV)感染模式与血清甲胎蛋白(AFP)水平的关系。方法:应用酶免疫检测法(ELISA)、聚合酶链反应(PCR)及放射免疫技术分别测定100例原发性肝癌患者血清乙型肝炎病毒指标(HBV-M)及AFP。结果:100例PHC患者中,HBV-M阳性88例(88％),阴性12例(12％),HBV-M阳性者AFP水平高于阴性者147 ng/mL,二者有非常显著性意义(P<0.01),且HBV-M阳性者AFP升高(68.4％)的比例明显高于HBV-DNA阴性者(31.6％)(P<0.01)。PHC患者HBV感染模式分析中,HBsAg、HBeAb、HBcAb阳性和HBV-DNA阳性最多,为56例(63.6％),其次为HBsAg、HBeAg、HBcAb和HBV-DNA阳性,为9例(10.2％)。结论:HBV是原发性肝癌发生的重要原因,在PHC患者中,AFP升高与HBV感染、复制相关。

RELATIVE STUDY BETWEEN HBV INFECTIOUS MODEL AND AFP LEVEL IN PRIMARY HEPATIC CANCER

Objective: To investigate the relationship between infection model of HBV and AFP level. Methods: Both HBV-M and AFP in the serum were determinated from 100 cases of patients with PHC by ELISA, PCR and radioimmunoassay. Results: The positive of HVB was 88 cases (88 %) and the negative 12 cases (12 %) respectively in the total 100 cases of patients with PHC. The AFP level in positive HBV-M was significantaly higher than that in negative one (P<0.01). It showed that (1)all the HBsAg, HBeAb, HbcAb and HBV-M positive were 56 cases (63.6 %); (2) the HBsAg, HBeAb, HBcAb and HBV-M positive were 9 cases (10.2 %) in the analysis of infection model of HBV. Conclusion: HVB is an important cause of PHC and AFP level increases is related to both infection and duplication of HBV.