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前列腺癌患者外周血中巨噬细胞移动抑制因子基因-173位点单核苷酸多态性的研究
引用本文:丁冠雄,华立新,徐郑,冯宁翰,宋宁宏,张炜,吴宏飞.前列腺癌患者外周血中巨噬细胞移动抑制因子基因-173位点单核苷酸多态性的研究[J].中华泌尿外科杂志,2007,30(1):379-381.
作者姓名:丁冠雄  华立新  徐郑  冯宁翰  宋宁宏  张炜  吴宏飞
作者单位:南京医科大学附属无锡市第二人民医院泌尿外科,214002;南京医科大学第一附属医院泌尿外科;
基金项目:江苏省卫生厅135重点学科基金
摘    要:目的 探讨前列腺癌(PCa)患者外周血中巨噬细胞移动抑制因子(MIF)基因-173位点单核苷酸多态性在PCa发生中的作用.方法采用病例对照研究方法提取259例PCa、301例非肿瘤非前列腺疾病患者外周血中基因组DNA,应用PCR-限制性片段长度多态性分析MIF基因-173位点的多态性,比较不同基因型与PCa易感性的关系,并分析基因多态性与年龄、吸烟情况、肿瘤家族史的关系.结果 PCa患者中携带*C等位基因比例为36%,显著高于对照组的15%;携带MIF-173*C等位基因的个体PCa发病风险为G/G基因型的2.96倍(OR=2.96,95%CI:1.92~4.57);年龄>70岁、浅吸烟、有肿瘤家族史人群携带MIF-173*C等位基因的个体PCa发病风险显著高于G/G基因型个体,校正OR值分别为3.66(95%CI:2.02~6.62),2.83(95%CI:1.07~7.45)和3.26(95%CI:1.24~8.55).结论 MIF-173*C等位基因可能与PCa发生有关,年龄、吸烟情况、肿瘤家族史是PCa发病中的重要影响因素.

关 键 词:前列腺肿瘤    基因多态性    巨噬细胞移动抑制因子    

Association of macrophage migration inhibitory factor gene-173 locus polymorphism and prostate cancer
DING Guan-xiong,HUA Li-xin,XU Zheng,FENG Ning-han,SONG Ning-hong,ZHANG Wei,WU Hong-fei.Association of macrophage migration inhibitory factor gene-173 locus polymorphism and prostate cancer[J].Chinese Journal of Urology,2007,30(1):379-381.
Authors:DING Guan-xiong  HUA Li-xin  XU Zheng  FENG Ning-han  SONG Ning-hong  ZHANG Wei  WU Hong-fei
Abstract:Objective To study the association of MIF-173 locus polymorphism and the risk of prostate cancer (PCa) in China. Methods A case control study including 259 PCa patients and 301 age-matched controls was conducted. The polymorphisms of MIF-173 locus were analyzed by poly-merase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique using genomic DNA isolated from peripheral blood lymphocytes. The correlations between the susceptibility to PCa and different genotypes were compared. The effect of age, smoking method and family history of canc-er were also analyzed. Results The rate of the MIF-173 * C variant allele of the PCa patients(n=259) was significantly higher than that of the controls (n=301) (36.0% vs 15.0%). The MIF-173 *C variant allele could significantly increase the risk of PCa (OR=2.96,95%CI: 1.92-4.57). Peo-ple with older age (age>70) or family history of cancer, who carried MIF-173 * C allele demonstra-ted a significantly increased risk in comparison with those carrying wild genotype of G/G(OR=3.66, 95%CI=2.02-6.62;OR=3.26, 95%CI=1.24-8.55). Conclusion These results suggested that polymorphisms of MIF-173 locus appear to influence the risk of PCa and may have synergistic effect with age and family history of cancer.
Keywords:Prostatic neoplasmsGenetic polymorphismMacrophage migration inhibitory factor
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