长期大量饮酒对大鼠性功能的影响

目的 本实验探讨长期大量饮酒对大鼠性功能的影响。方法 将30只雄性大鼠随机分为对照组。20％酒精剂量组和40％酒精剂量组。分别以生理盐水、20%和40％食用酒精各2mL给大鼠灌胃，每日1次。3个月后，观察各组大鼠性行为和药物诱发阴茎勃起的变化；用酶放大物理发光仪测定各组大鼠血清睾酮的含量：测定阴茎平滑肌中一氧化氮合成酶的总量。结果 与对照组相比，20％酒精剂量组和40％酒精剂量组大鼠性行为、血清睾酮含量和阴茎组织中一氧化氮合成酶活性有统计学意义（P〈0．05），40％酒精剂量组大鼠的药物诱发阴茎勃起实验也受到抑制（P〈0．05）。结论 大鼠长期大量饮酒后性功能障碍，其机制与血浆睾酮含量降低，阴茎组织中一氧化氮合成酶活性降低有美。

Effects of long term and excessive intake of ethanol on sexual function of rats

[Objective] To investigate the effects of long term and excessive intake of ethanol on sexual function of the rats. [Methods] Thirty adult male Wistar rats were randomly divided into three groups: the control group,20% ethanol group and 40% ethanol group. 0.9% natric chloride、20% and 40% ethanol solution were administered with a dose of 2ml through gastric tubes in the rats every day. Three monthes later, the effects of ethanol on sexual function were studied by sexual behavior, the number of apomorphine-induced penile erection, testosterone in the sera and nitric oxide synthase(NOS) in the penis. [Results] Compared with the control group, sexual behavior,testosterone in the sera and NOS activity in the penis of 20% ethanol group and 40% ethanol group were inhibited significantly (P＜0.05). The number of apomorphine-induced penile erection was also decreased notably in 40%ethanol group(P＜0.05). [Conclusion] Long term and excessive intake of ethanol can induce sexual dysfunction in rats. The decline of testosterone in the sera and NOS in the penis may be responsible for it.