| 苦荞麦对糖尿病大鼠血糖 蛋白非酶糖基化反应的影响 |
| |
| 引用本文： | 刘洋,柳春,近藤隆一郎,松原惠理.苦荞麦对糖尿病大鼠血糖 蛋白非酶糖基化反应的影响[J].辽宁中医药大学学报,2009(5). |
| |
| 作者姓名： | 刘洋 柳春 近藤隆一郎 松原惠理 |
| |
| 作者单位： | 辽宁中医药大学生化教研室;九州大学; |
| |
| 摘 要： | 目的:研究苦荞麦提取物对STZ诱导的糖尿病大鼠血糖、蛋白非酶糖基化反应的影响。方法:用链脲左菌素(STZ)诱导糖尿病大鼠模型,并于第3周开始给予苦荞麦高、中、低(200,100,50mg/kg·d)剂量和氨基胍(100mg/kg·d)剂量处理12周。上述动物于第12周末尾部取血,用血糖仪测定大鼠即时血糖。用酶联免疫吸附分析法(ELISA)测定糖化血红蛋白含量。用荧光分光光度法测定晚期糖基化终末产物含量。计量资料采用SPSS14.0进行方差分析。结果:苦荞麦高、中剂量明显降低糖尿病大鼠血糖、抑制糖基化产物的形成(P<0.01),并且苦荞麦高剂量组的治疗效果优于氨基胍组。结论:中药苦荞麦的提取物具有降低血糖、抑制大鼠体内蛋白非酶糖基化反应的作用。
|
| 关 键 词： | 苦荞麦 血糖（BG） 糖化血红蛋白（GHbA1c） 晚期糖基化终末产物（AGEs） |
Effect of Buckwheats on Blood Glucose Non-enzymatic Protein Glycated Reaction in STZ-induced Diabetic Rats |
| |
| LIU Yang,LIU Chun,Ryuichiro Kondo,Eri Matsubara.Effect of Buckwheats on Blood Glucose Non-enzymatic Protein Glycated Reaction in STZ-induced Diabetic Rats[J].Journal of Liaoning University of Traditional Chinese Medicine,2009(5). |
| |
| Authors: | LIU Yang LIU Chun Ryuichiro Kondo Eri Matsubara |
| |
| Institution: | 1.Department of Biochemistry of Liaoning University of TCM;Shenyang 110032;Liaoning;China;2.Kyushu University;Fukuoka 8120053;Japan |
| |
| Abstract: | Objective:To observe the effect of Buckwheats on blood glucose,products of non-enzymatic protein glycated reaction in STZ-induced diabetic rats. Methods:Diabetic rats induced by STZ had been orally administrated Buckwheats extract(50,100,200 mg/kg body weight/d) or aminoguanidine(100 mg/kg body weight/d) for 12 weeks. At the end of 12th week,the blood glucose levels were measured by the Blood Glucose Meter; glycated hemoglobin levels by Rat Glycated hemoglobin A1c,GHbA1c ELISA Kit; advanced glycation end-pr... |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
