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Diminished interleukin-2 activity production in cancer patients bearing solid tumors and its relationship with natural killer cells |
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| Authors: | A Rey B Klein D Zagury C Thierry B Serrou |
| Affiliation: | 2. Laboratoire d''Immunopharmacologie des Tumeurs, INSERM U-236, CNRS ERA 844, Centre Paul Lamarque, BP 5054, 34033 Montpellier Cédex, France;1. Université Pierre et Marie Curie, UER 61, 4 Place Jussieu, Tour 32, 75005 Paris, France |
| Abstract: | Interleukin-2 (IL-2) activity production by stimulated peripheral blood lymphocytes (PBL) from solid tumor bearing cancer patients was lower than in normal subjects. Natural-killer (NK) cell activity in the PBL of cancer patients was very significantly correlated to IL-2 activity production (P less than 0.001). These results might suggest a central role for IL-2 in the immune dysfunctions in cancer patients, and the possible use of IL-2 as an immunological response modifier in these patients. |
| Keywords: | interleukin-2 natural killer cells cancer patients |
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