乳腺癌循环肿瘤细胞生物学特性的研究进展

目的：总结乳腺癌循环肿瘤细胞生物学特性相关的研究进展。方法：以“乳腺肿瘤、循环肿瘤细胞和微转移”为关键词，系统检索PubMed、Ovid、EMBASE、WebofScience的中国生物医学文献数据库等医学数据库（2000-01—2011—12）。纳入标准：乳腺癌循环肿瘤细胞生物学特性。根据纳入标准，符合分析的文献34篇。结果：乳腺癌循环肿瘤细胞具有高度异形性，细胞增殖活性低，表达激素受体、血管生成相关分子等多种标志，且与上皮细胞间质化、肿瘤干细胞及肿瘤自身种植等密切相关。循环肿瘤细胞具有与原发灶、转移灶内肿瘤细胞明显不同的生物学特征。结论：乳腺癌循环肿瘤细胞具有自身独特的生物学特性，进一步深入研究其生物学特性有助于加深对肿瘤播散和转移机制的认识。

Progress in biological characteristics of circulating breast-tumor cells

OBJECTIVE： To summarize the progress in biological characteristics of circulating breast-tumor cells. METHODS： A comprehensive search strategy for review literature was performed towards the electronic databases including PubMed, Ovid, EMBASE, Web of Science, and Chinese Biomedical Literature database using terms ＂breast neo plasm＂, ＂circulating tumor cells＂, ＂micrometastasis＂ （ 2000-01 - 2011-12 ）. Eligibility Criteria ： Publications related to bio- logical characteristics of circulating breast-tumor cells were included in this review and 34 literatures were cited. RE- SULTS： The biological characteristics of circulating breast-tumor cells were different from that of cells in primary and metastatic tumor including cellular atypia, proliferation, expressed molecules, angiogenesis, and relationship with epithelial to mesenchymal transition,tumor stem cell and tumor self-seeding. CONCLUSION： With respect to biological characteristics of circulating breast-tumor cells, further investigation on these characteristics may help enhance the understanding of tumor disseminateion and metastasis.