Antiplasmodial activity of Setaria megaphylla |
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Authors: | Okokon Jude E Ubulom Peace M E Udokpoh Aniekan E |
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Institution: | Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com |
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Abstract: | The antimalarial activity of an ethanol leaf extract of Setaria megaphylla was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections. Setaria megaphylla (100-300 mg/kg/day) exhibited a significant (p < 0.05) blood schizonticidal activity in 4-day early infection and in established infection with a significant (p < 0.05) mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The leaf extract possesses a promising antiplasmodial activity in vivo which can be exploited in malaria therapy. |
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Keywords: | Setaria megaphylla malaria Plasmodium berghei berghei |
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