Some extensions to a new approach for interim analysis in clinical trials |
| |
Authors: | B Falissard J Lellouch |
| |
Affiliation: | INSERM U 169, Villejuif, France. |
| |
Abstract: | There already exists many methods for group sequential analysis of clinical trials. A new approach suggests to preserve the overall type I error alpha by requiring that a succession of interim analyses be significant at the alpha level. In this paper, this procedure is extended. A rule for early acceptance of H0 is presented, with an extension for flexible number and times of analyses. A real example is given. |
| |
Keywords: | |
|
|