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| 健胃愈疡片治疗消化性溃疡314例临床疗效与安全性 | |
| 引用本文： | 梁小庆,丁洪明,李爱国,常胜,王宪国,何俊,赵怡. 健胃愈疡片治疗消化性溃疡314例临床疗效与安全性[J]. 中国临床药理学与治疗学, 2007, 12(7): 835-837 |
| 作者姓名： | 梁小庆 丁洪明 李爱国 常胜 王宪国 何俊 赵怡 |
| 作者单位： | 1. 东南大学医学院附属中大医院药剂科 2. 中医科,南京,210009,江苏 3. 内蒙古自治区医院中医科,呼和浩特,010000,内蒙古 4. 绍兴市中医院肿瘤科,绍兴312000,浙江 5. 常州市中医院消化溃疡科,常州,213000,江苏 6. 常州市德安医院消化内科,常州,213003,江苏 7. 中国人民解放军第454医院肿瘤科,南京,210001,江苏 |
| 摘 要： | 目的：观察健胃愈疡片治疗消化性溃疡的临床疗效与安全性。方法：临床确诊的消化性溃疡患者按先后顺序随机入组，试验组314例口服健胃愈疡片，对照组132例口服雷尼替丁胶囊，两组均治疗4周为一疗程。结果：健胃愈疡片治疗消化性溃疡，溃疡痊愈率为59．87％，有效率为91．40％，痊愈患者6个月后溃疡复发率为12．24％，治疗后疼痛缓解率为93．00％，疼痛消失率为79．33％；对照组溃疡痊愈率为58．33％，有效率为89．39％，痊愈患者6个月后溃疡复发率为14．04％，治疗后疼痛缓解率为88．46％，疼痛消失率为72．30％；两组比较，差异无统计学意义。两组均未发现与药物相关的不良反应。结论：健胃愈疡片治疗消化性溃疡疗效确切，安全可靠。 |
| 关 键 词： | 健胃愈疡片 雷尼替丁 消化性溃疡 临床疗效 安全性 |
| 文章编号： | 1009-2501（2007）07-0835-03 |
| 修稿时间： | 2007-06-18 |
Clinical efficacy and safety evaluation of Jianweiyuyangpian in treatment of 314 patients with peptic ulcer |
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| LIANG Xiao-qing,DING Hong-ming,LI Ai-guo,CHANG Sheng,WANG Xian-guo,HE Jun,ZHAO Yi. Clinical efficacy and safety evaluation of Jianweiyuyangpian in treatment of 314 patients with peptic ulcer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 835-837 | |
| Authors: | LIANG Xiao-qing DING Hong-ming LI Ai-guo CHANG Sheng WANG Xian-guo HE Jun ZHAO Yi |
| Affiliation: | 1.Department of Pharmacy , 2.Department of Traditional Chinese Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu, China ; 3.Department of Traditional Chinese Medicine, Inner Mongolia Autonomous Region Hospital, Hohhot 010600, Inner Mongolia, China ; 4.Department of Tumor , Shaoxing Hospital of Traditional Chinese Mediche , Shaoxing 312000, Zhejiang, China; 5.Department of Coction Anabrosis, Changzhou Hospital of Traditional Chinese Mediche, Changzhou 213000, Jiangsu, China ; 6.Department of Coction Medical, Dean Hospital of Changzhou, Changzhou 213003, Jiangsu, China; 7.Department of Tumor, 454th Hospital of PLA , Nanjing 210002, Jiangsu, China |
| Abstract: | AIM:To evaluate the clinical efficacy and safety of Jianweiyuyangpian in the treatment of 314 patients with peptic ulcer. METHODS: 446 patients with peptic ulcer were randomly divided into two groups of treatment group and control group. 314 patients in treatment group were administered with Jianweiyuyangpian orally and 132 patients in control group with ranitidine capsules for 4 weeks. RESULTS: After treating for 4 weeks the ulcer cure rate,efficacy rate, six month recurance rate, pain relief rate and pain disappearance rate of treatment group were 59.87%, 91.40%, 12.24%, 93.00% and 79.33% respectively, while those of control group were 58.33%, 89.39%, 14.04%, 88.46% and 72.30% respectively. The differences between two groups were not significant(P>0.05). Both of the two groups had no adverse event. CONCLUSION: Jianweiyuyangpian is a safe and effective drug for treating peptic ulcer. |
| Keywords: | Jianweiyuyangpian ranitidine peptic ulcer clinical efficacy safety |
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