Liver fat is not a marker of metabolic risk in lean premenopausal women

We examined the independent associations among abdominal adipose tissue (AT) depots, liver fat, cardiorespiratory fitness (CRF), and metabolic risk factors in 86 lean premenopausal women. We measured abdominal AT and liver fat by computed tomography (CT), and CRF by a maximal treadmill exercise test. Liver fat was not related to any abdominal AT depot, metabolic risk factor, or CRF (P > .10). Visceral AT mass (kilograms) remained a significant (P < .05) predictor of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C), and LDL-C/HDL-C after statistical adjustment for CRF. Abdominal subcutaneous AT mass was also a significant (P < .05) correlate of TC/HDL-C and LDL-C/HDL-C after control for CRF. Visceral AT remained a significant predictor (P < .05) of TC and LDL-C after control for abdominal subcutaneous AT. Conversely, subcutaneous AT did not remain a significant correlate after control for visceral AT. However, the deep subcutaneous AT depot remained significantly associated with LDL-C, TC/HDL-C, and LDL-C/HDL-C after control for visceral AT. In contrast, visceral AT remained correlated with triglycerides (TG) alone, after control for the deep subcutaneous AT. These observations suggest that liver fat is not a determinant of metabolic risk in lean women. Conversely, both visceral and the deep subcutaneous depot are determinants of metabolic risk in premenopausal woman despite the absence of obesity.