Serum basic fibroblast growth factor as a marker of reflux nephropathy |
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Authors: | Kobayashi Hiroyuki Miyakita Hideshi Yamataka Atsuyuki Koga Hiroyuki Lane Geoffrey J Miyano Takeshi |
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Institution: | a Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan b Department of Urology, Tokai University School of Medicine, Kanagawa, Japan |
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Abstract: | PurposeThe authors investigated whether serum basic fibroblast growth factor (b-FGF) can be used as a noninvasive marker of renal parenchymal damage (scarring) in cases of vesicoureteric reflux (VUR).MethodsSerum levels of b-FGF were measured in 120 children with known grade III to grade V VUR and 21 controls using a standard enzyme-linked immunosorbent assay technique.ResultsSixty-five children had grade III VUR, 39 had grade IV, and 16 had grade V. Renal scarring was seen in 43 children on radionuclide scanning. There were no significant differences between serum b-FGF levels for different grades of VUR without scarring and controls. However, serum b-FGF levels were significantly higher in VUR patients with renal scarring than in patients with VUR without renal scarring (P < .001).ConclusionsThis report is the first to document serum b-FGF profiles in children with VUR and renal scarring. The authors recommend measuring it as a simple, noninvasive marker of renal scarring in cases of VUR. |
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Keywords: | Vesicoureteral reflux basic fibroblast growth factor renal scarring reflux nephropathy |
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