In situ inhibition of uterine activity by indomethacin: possible relevance to preterm labor prevention after fetal surgery |
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Authors: | Garza Jennifer Clayton Nicholas Kaviani Amir Maher Timothy J Fauza Dario |
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Affiliation: | a Departments of Surgery, Children’s Hospital and Harvard Medical School, Boston, MA, USA b Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA c Harvard Center for Minimally Invasive Surgery, Boston, MA, USA |
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Abstract: | PurposeThis report is an analysis of the effects of local indomethacin delivery on uterine activity in vitro.MethodsIsolated strips of time-dated pregnant rats’ myometrium were placed within controlled tissue baths. Spontaneous muscular activity was recorded by a force transducer connected to a polygraph at cumulative concentrations of indomethacin. Statistical analysis was by single-factor analysis of variance (ANOVA), with P values of less than .05 considered significant.ResultsWithin a narrow concentration range, the effects of indomethacin on frequency and amplitude of myometrial contractions were nonmonotonic, with an increase in frequency at levels that began to depress amplitude. However, both amplitude and frequency were significantly depressed and eventually totally abolished at most concentrations studied (P < .05).ConclusionsIndomethacin administered in situ consistently inhibits or completely arrests overall myometrial activity. The concept of local myometrial delivery of indomethacin, possibly via slow release systems, may prove clinically useful as an adjuvant to its systemic administration in preterm labor prevention after fetal surgery, warranting further trials in vivo. |
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Keywords: | Premature labor fetal surgery uterus myometrium indomethacin |
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