Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Authors:	Kate M. Crossley Shruti Agnihotri Joga Chaganti Michael L. Rodriguez Leon Patrick McNally Nagagopal Venna Sarah E. Turbett Matthew Gutman Adrienne Morey Igor J. Koralnik Bruce J. Brew

Affiliation:	1.Department of Neurology,St Vincent’s Hospital,Sydney,Australia;2.Division of Neuro Immunology, Center for Virology and Vaccine Research,Beth Deaconess Medical Center,Boston,USA;3.Department of Radiology,St Vincent’s Hospital,Sydney,Australia;4.Department of Neuropathology,St Vincent’s Hospital,Sydney,Australia;5.Department of Molecular Medicine,St Vincent’s Hospital,Sydney,Australia;6.Department of Neurology,Massachusetts General Hospital,Boston,USA;7.Department of Infectious Diseases,Massachusetts General Hospital,Boston,USA;8.Department of Neurosurgery,St Vincent’s Hospital,Sydney,Australia;9.Department of Anatomical Pathology,St Vincent’s Hospital,Sydney,Australia;10.Department of Neurology,St Vincent’s Hospital, Sydney Australia, also Peter Duncan Neurosciences Unit Neurosciences Program, St Vincent’s Centre for Applied Medical Research,Sydney,Australia;11.Department of Infectious Diseases and Immunology,St Vincent’s Hospital, Sydney Australia, also Peter Duncan Neurosciences Unit Neurosciences Program, St Vincent’s Centre for Applied Medical Research,Sydney,Australia

Abstract:	We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

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